Now showing items 1-3 of 3
Investigation of the role of TNF-? converting enzyme (TACE) in the inhibition of cell surface and soluble TNF-? production by acute ethanol exposure.
(Public Library of Science, 2/3/2012)
Toll-like receptors (TLRs) play a fundamental role in the immune system by detecting pathogen associated molecular patterns (PAMPs) to sense host infection. Ethanol at doses relevant for humans inhibits the pathogen induced ...
Re-annotation is an essential step in systems biology modeling of functional genomics data.
(Public Library of Science, 5/14/2010)
One motivation of systems biology research is to understand gene functions and interactions from functional genomics data such as that derived from microarrays. Up-to-date structural and functional annotations of genes are ...
Role of an iron-dependent transcriptional regulator in the pathogenesis and host response to infection with Streptococcus pneumoniae.
(Public Library of Science, 2/20/2013)
Iron is a critical cofactor for many enzymes and is known to regulate gene expression in many bacterial pathogens. Streptococcus pneumoniae normally inhabits the upper respiratory mucosa but can also invade and replicate ...