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dc.contributor.authorFinch, Tabitha M.
dc.contributor.authorZhao, Nan
dc.contributor.authorKorkin, Dmitry
dc.contributor.authorFrederick, Katy H.
dc.contributor.authorEggert, Lori S.
dc.date.accessioned2015-10-09T19:50:51Z
dc.date.available2015-10-09T19:50:51Z
dc.date.issued4/2/2014
dc.identifier.issn1932-6203
dc.identifier.urihttp://hdl.handle.net/11668/2516
dc.identifier.urihttp://dx.doi.org/10.1371/journal.pone.0092587
dc.description.abstractAs species evolve, they become adapted to their local environments. Detecting the genetic signature of selection and connecting that to the phenotype of the organism, however, is challenging. Here we report using an integrative approach that combines DNA sequencing with structural biology analyses to assess the effect of selection on residues in the mitochondrial DNA of the two species of African elephants. We detected evidence of positive selection acting on residues in complexes I and V, and we used homology protein structure modeling to assess the effect of the biochemical properties of the selected residues on the enzyme structure. Given the role these enzymes play in oxidative phosphorylation, we propose that the selected residues may contribute to the metabolic adaptation of forest and savanna elephants to their unique habitats.
dc.publisherPublic Library of Science
dc.relation.ispartofseriesPLoS ONE (Volume 9, Issue 4)
dc.subject.otherAdaptation
dc.subject.otherAnimals
dc.subject.otherElectron Transport Complex I
dc.subject.otherElectron Transport Complex I: genetics
dc.subject.otherElephants
dc.subject.otherElephants: physiology
dc.subject.otherEvolution
dc.subject.otherGenetic
dc.subject.otherGenetic: physiology
dc.subject.otherMitochondrial Proteins
dc.subject.otherMitochondrial Proteins: genetics
dc.subject.otherMolecular
dc.subject.otherPhysiological
dc.subject.otherSelection
dc.titleEvidence of positive selection in mitochondrial complexes I and V of the African elephant.
dc.typeArticle
dc.publisher.departmentDepartment of Basic Sciences
dc.publisher.collegeCollege of Veterinary Medicine
dc.identifier.doi10.1371/journal.pone.0092587


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