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    Evaluation of the Effects of Murine Macrophage Cells on Biocorrosion of Two Implant Alloys

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    etd-07042001-180551.pdf (777.7 Kb )
    Author
    Parker, Suzanne Hutchinson.
    Item Type
    Thesis
    Advisor
    Bumgardner, Joel D.
    Committee
    Zardiackas, Lyle D.
    Wipf, David O.
    Pinchuk, George
    McLaughlin, Ronald M.
    Elder, Steve H.
    Metrics
    
    Abstract
    Titanium and 316L stainless steel are popular orthopedic implant alloys because of their mechanical properties and corrosion resistance. The central hypotheses of this research were to determine if the adsorption of cells onto implant surfaces would alter their electrochemical corrosion properties and if released metal ions would stimulate macrophages. Analysis of supernatants and electrochemical corrosion tests were conducted on 316L SS and Ti with macrophages attached to evaluate their interactions. Results indicated that cells attached to alloys do alter their corrosion behavior by significantly increasing equilibrium potentials. Cells attached to 316L SS significantly increased charge transfer and the release of Ni, which is known to cause hypersensitivity. A difference in cell stimulation was seen between controls cells on TCP and cells cultured on the alloys. Significant findings of this study include alterations in alloy corrosion behavior and cell stimulation.
    Degree
    Master of Science
    Major
    Biomedical Engineering
    College
    College of Engineering
    Department
    Department of Agricultural and Biological Engineering.
    URI
    https://hdl.handle.net/11668/20231
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    • Theses and Dissertations
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    Mississippi State University Libraries
    395 Hardy Rd
    P.O. Box 5408, Mississippi State, MS 39762-5408
    (662) 325-7668
    (662) 325-0011
    (662) 325-8183
    Contact repository admin Report a problem Terms of use Privacy policy Accessibility MSU Legal
     

     

    Mississippi State University Libraries
    395 Hardy Rd
    P.O. Box 5408, Mississippi State, MS 39762-5408
    (662) 325-7668
    (662) 325-0011
    (662) 325-8183
    Contact repository admin Report a problem Terms of use Privacy policy Accessibility MSU Legal