Show simple item record

dc.contributor.advisorArcher, Todd M
dc.contributor.authorCridge, Harry
dc.date.accessioned2020-01-21T19:19:49Z
dc.identifier.urihttps://hdl.handle.net/11668/16495
dc.description.abstractExisting pharmacokinetic monitoring tools for cyclosporine fail to correlate with clinical response. In dogs, pharmacodynamic monitoring of nuclear factor of activated T cell (NFAT) regulated cytokines is thought to provide a better overall evaluation of the immune response to cyclosporine than blood levels; however, such monitoring tools are not available in cats. In this study, we designed and optimized a protocol for maximal T lymphocyte stimulation in cats. This is the first step in the development of a pharmacodynamic monitoring tool for cyclosporine in cats based on expression of NFAT-regulated cytokines. We also confirmed that cyclosporine has anti-lymphocytic properties in cats, and we were the first to document induction of apoptosis by cyclosporine in cats. Differences in individual patient response to cyclosporine may be influenced by apoptotic response of lymphocytes to cyclosporine. Additional studies are required to optimize and validate polymerase chain reaction monitoring of NFAT-regulated cytokines for cyclosporine-mediated immunosuppression.en_US
dc.description.sponsorshipThis work was supported by a grant from the Mississippi State University College of Veterinary Medicine Office of Research and Graduate Studies.en_US
dc.subjectcyclosporineen_US
dc.subjectfelineen_US
dc.subjectpharmacodynamic monitoringen_US
dc.titlePreliminary investigations into pharmacodynamic monitoring of cyclosporine in catsen_US
dc.typeGraduate Thesisen_US
dc.publisher.departmentDepartment of Clinical Sciencesen_US
dc.publisher.collegeCollege of Veterinary Medicineen_US
dc.date.authorbirth1993-05-21
dc.subject.degreeMaster of Scienceen_US
dc.subject.majorVeterinary Medical Researchen_US
dc.contributor.committeePinchuk, Lesya M
dc.contributor.committeeMackin, Andrew J
dc.contributor.committeeThomason, John M
dc.contributor.committeeGrace, Sharon F
dc.date.defense2020-01-09
dc.rights.embargodescriptionVisible to MSU only for 1 yearen_US
dc.rights.embargotermsforeveren_US
dc.rights.embargoliftdate10000-01-01
dc.date.graduation2020-05-01


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record