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dc.contributor.advisorBridges, M. Susan
dc.contributor.authorSanders, William Shane
dc.date2011
dc.date.accessioned2019-09-17T14:01:49Z
dc.date.available2019-09-17T14:01:49Z
dc.date.issued3/30/2011
dc.identifier.urihttps://hdl.handle.net/11668/15054
dc.description.abstractProteins provide evidence that a given gene is expressed, and machine learning algorithms can be applied to various proteomics problems in order to gain information about the underlying biology. This dissertation applies machine learning algorithms to proteomics data in order to predict whether or not a given peptide is observable by mass spectrometry, whether a given peptide can serve as a cell penetrating peptide, and then utilizes the peptides observed through mass spectrometry to aid in the structural annotation of the chicken genome. Peptides observed by mass spectrometry are used to identify proteins, and being able to accurately predict which peptides will be seen can allow researchers to analyze to what extent a given protein is observable. Cell penetrating peptides can possibly be utilized to allow targeted small molecule delivery across cellular membranes and possibly serve a role as drug delivery peptides. Peptides and proteins identified through mass spectrometry can help refine computational gene models and improve structural genome annotations.
dc.publisherMississippi State University
dc.subject.lcshPeptides--Analysis.
dc.subject.lcshPeptides--Biotechnology.
dc.subject.lcshChickens--Genome mapping.
dc.subject.lcshProteomics.
dc.subject.othermachine learning
dc.subject.otherproteomics
dc.subject.othermapping algorithms
dc.subject.othercell penetrating peptides
dc.subject.otherpeptide observability
dc.subject.otherproteogenomic mapping
dc.subject.otherchicken
dc.titleMachine learning and mapping algorithms applied to proteomics problems
dc.typeDissertation
dc.publisher.departmentDepartment of Biochemistry and Molecular Biology.
dc.date.authorbirth1979
dc.subject.degreeDoctor of Philosophy
dc.contributor.committeeHansen, A. Eric
dc.contributor.committeeBoyle, A. John
dc.contributor.committeeWilleford, O. Kenneth
dc.contributor.committeeBurgess, C. Shane


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