The effect of short and long-term NSAID administration on osteotomy healing in dogs
Item TypeGraduate Thesis
AdvisorButler, James Ryan
Baumgartner, Wes A.
Pruett, Stephen B.
The ability of NSAIDs to delay bone healing has been long known, although the extent and exact mechanism remains elusive. The present study evaluates the effect of short duration NSAID on bone healing in dogs following experimental tibial osteotomy. Carprofen was administered twice daily for either 0, 2, or 8 weeks following surgery. Bone healing was evaluated radiographically using RUST scoring at 4 and 8 weeks postop. Postmortem, quantitative CT of for bone mineral density analysis, histologic cartilage:callus ratio of the fracture, and biomechanical testing were performed. Biomechanically, stiffness and maximum stress were higher in dogs that received no carprofen than those that received 8 weeks. Radiographic healing scores were the same for dogs which did not receive carprofen and those receiving a short course, but both were more healed than dogs which received 8 weeks of carprofen. There was no treatment effect on cartilage:callus ratio or bone mineral density.