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dc.contributor.advisorEmerson, Joseph P.en_US
dc.contributor.authorKhanal, Prakashen_US
dc.date.accessioned2019-07-15T17:28:25Zen_US
dc.date.available2019-07-15T17:28:25Zen_US
dc.date.issued2019
dc.identifier.urihttps://hdl.handle.net/11668/14529en_US
dc.description.abstractTranscription factors (TFs) are proteins that respond to a specific chemical signal and bind to DNA. In some bacteria, TFs control transition metal ion homeostasis by specifically binding with a particular metal ion or ions and then interacting with DNA. Although most first row metal ions are required as micronutrients for life, many of them can cause cellular damage or death if their concentrations are too high; this makes these TFs and their biological interactions excellent targets for drug development. The bacteria, Streptococcus pneumoniae is a pathogenic microorganism responsible for a range of diseases that target the young and the old, including pneumonia, meningitis, and bacteremia. Herein, we describe our efforts to study the Streptococcus pneumoniae TF responsible for copper(II) ion homeostasis. This thesis describes the classical biochemical techniques used to over-express and purify CopR. It also describes a series of preliminary characterization data associated with this novel copper(II)-dependent TF.en_US
dc.language.isoen_USen_US
dc.publisherMississippi State Universityen_US
dc.titlePurification and characterization of CopR, a copper(II) dependent transcription factoren_US
dc.typeGraduate Thesisen_US
dc.publisher.departmentDepartment of Chemistryen_US
dc.publisher.collegeCollege of Arts and Sciencesen_US
dc.publisher.officeOffice of the Graduate Schoolen_US
dc.rights.embargo7/17/2022en_US
dc.source.institutionMississippi State Universityen_US
dc.subject.degreeMaster of Scienceen_US
dc.subject.majorChemistryen_US
dc.contributor.committeeFitzkee, Nicholas C.en_US
dc.contributor.committeeMlsna, Debra Annen_US
dc.contributor.committeeTravisen_US


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