Now showing items 1-10 of 17
Spatiotemporal structure of molecular evolution of H5N1 highly pathogenic avian influenza viruses in Vietnam.
(Public Library of Science, 1/8/2010)
BACKGROUND: Vietnam is one of the countries most affected by outbreaks of H5N1 highly pathogenic avian influenza viruses. First identified in Vietnam in poultry in 2001 and in humans in 2004, the virus has since caused 111 ...
Cross-Ontology multi-level association rule mining in the Gene Ontology.
(Public Library of Science, 10/12/2012)
The Gene Ontology (GO) has become the internationally accepted standard for representing function, process, and location aspects of gene products. The wealth of GO annotation data provides a valuable source of implicit ...
A perspective on multiple waves of influenza pandemics.
(Public Library of Science, 4/23/2013)
BACKGROUND: A striking characteristic of the past four influenza pandemic outbreaks in the United States has been the multiple waves of infections. However, the mechanisms responsible for the multiple waves of influenza ...
Proteomics-based systems biology modeling of bovine germinal vesicle stage oocyte and cumulus cell interaction.
(Public Library of Science, 6/21/2010)
BACKGROUND: Oocytes are the female gametes which establish the program of life after fertilization. Interactions between oocyte and the surrounding cumulus cells at germinal vesicle (GV) stage are considered essential for ...
Ultrasonic incisions produce less inflammatory mediator response during early healing than electrosurgical incisions.
(Public Library of Science, 9/12/2013)
As the use of laparoscopic surgery has become more widespread in recent years, the need has increased for minimally-invasive surgical devices that effectively cut and coagulate tissue with reduced tissue trauma. Although ...
Investigation of the role of TNF-? converting enzyme (TACE) in the inhibition of cell surface and soluble TNF-? production by acute ethanol exposure.
(Public Library of Science, 2/3/2012)
Toll-like receptors (TLRs) play a fundamental role in the immune system by detecting pathogen associated molecular patterns (PAMPs) to sense host infection. Ethanol at doses relevant for humans inhibits the pathogen induced ...
Re-annotation is an essential step in systems biology modeling of functional genomics data.
(Public Library of Science, 5/14/2010)
One motivation of systems biology research is to understand gene functions and interactions from functional genomics data such as that derived from microarrays. Up-to-date structural and functional annotations of genes are ...
Identifying blood biomarkers and physiological processes that distinguish humans with superior performance under psychological stress.
(Public Library of Science, 12/18/2009)
BACKGROUND: Attrition of students from aviation training is a serious financial and operational concern for the U.S. Navy. Each late stage navy aviator training failure costs the taxpayer over $1,000,000 and ultimately ...
Extreme Evolutionary Conservation of Functionally Important Regions in H1N1 Influenza Proteome
(Public Library of Science, 11/25/2013)
Zebrafish kidney phagocytes utilize macropinocytosis and Ca+-dependent endocytic mechanisms.
(Public Library of Science, 2/2/2009)
BACKGROUND: The innate immune response constitutes the first line of defense against invading pathogens and consists of a variety of immune defense mechanisms including active endocytosis by macrophages and granulocytes. ...